We are immersed in a moment of change. There is no doubt. In all areas of society, including, very explicitly, the field of agriculture, forestry, and ecology. This change is accompanied by a growing interest in seeking new ways of thinking, conceiving and relating to the environment and, in particular, to the land that is home to the resources used for productive purposes. This search for new production models drive the Polyfarming project and, with it, the ‘Manual for the design and implementation of a regenerative agri-food model: the Polyfarming system’ that I am pleased to present. This extensive document explains the various agricultural, livestock and forestry management options that can be applied holistically in agroforestry farms in the Mediterranean climate.